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A preliminary study of IgG4 expression and its prognostic significance in oral squamous cell carcinoma.
- Source :
-
BMC cancer [BMC Cancer] 2024 Mar 04; Vol. 24 (1), pp. 294. Date of Electronic Publication: 2024 Mar 04. - Publication Year :
- 2024
-
Abstract
- Background: IgG4, which plays a pivotal role in the progression of phenotypically diverse tumors, serves as a prognostic marker because of its influence on cancer immunity. Nevertheless, the functions of IgG4 in tongue squamous cell carcinoma (TSCC) remained to be identified.<br />Methods: To evaluate the significance of IgG4 expression in TSCC, we performed immunohistochemical analysis of patients with TSCC (n = 50) to evaluate the correlation of IgG4 expression with patients' clinicopathological features and prognoses.<br />Results: Higher IgG4 expression detected in TSCC tissues was associated with the less advanced mode of invasion (Yamamoto-Kohama [YK] 1-3) (P = 0.031) and with well-differentiated TSCC (P = 0.077). Kaplan-Meier analyses revealed that the higher IgG4 expression group exhibited better prognosis indicated by overall survival (OS) (P = 0.04) and recurrence-free survival (RFS) (P = 0.016). Univariate analysis of OS indicated that IgG4 expression was associated with longer OS (P = 0.061), and multivariate analysis of RFS revealed that IgG4 expression served as an independent prognostic factor for longer RFS (P = 0.005).<br />Conclusion: These results indicate that relatively higher IgG4 levels serve as a favorable prognostic factor for TSCC.<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38438903
- Full Text :
- https://doi.org/10.1186/s12885-024-12048-5