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Two new glycosides from the root bark of Paeonia ostii .

Authors :
Kong C
Wang K
Sun L
Qin S
Wang R
Xu F
Source :
Natural product research [Nat Prod Res] 2024 Mar 03, pp. 1-7. Date of Electronic Publication: 2024 Mar 03.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Two new glycosides, ethyl- O-β-D -furanosyl-(1→6)- O-β-D- glucopyranoside ( 1 ) and (5-'')-galloyl-ethyl- O-β-D -furanosyl-(1→6) -O-β-D -glucopyranoside ( 2 ), together with eight known compounds ( 3 - 10 ) were obtained from the n -BuOH extraction of Paeonia ostii . Their structures were identified via the extensive spectroscopic analysis. Compounds 1 , 3-10 exhibited the anti-inflammation activities, which inhibited the production of NO, TNF- α and IL-1 β in LPS-induced RAW264.7 cells with IC <subscript>50</subscript> values ranging from 6.00 to 86.78 µ Μ.

Details

Language :
English
ISSN :
1478-6427
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
38433399
Full Text :
https://doi.org/10.1080/14786419.2024.2324372