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Polyacetylenes from Saposhnikovia divaricata and their anticancer activity.
- Source :
-
Fitoterapia [Fitoterapia] 2024 Apr; Vol. 174, pp. 105876. Date of Electronic Publication: 2024 Feb 29. - Publication Year :
- 2024
-
Abstract
- Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4 <superscript>+</superscript> probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC <subscript>50</subscript> value of 11.66 μM against HEPG2.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.<br /> (Copyright © 2023. Published by Elsevier B.V.)
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 174
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 38431027
- Full Text :
- https://doi.org/10.1016/j.fitote.2024.105876