Polyacetylenes from Saposhnikovia divaricata and their anticancer activity.

Authors :: Sun Y
Liu Y
Jiang P
Wang SY
Pan J
Guan W
Wang YX
Kuang HX
Wang YH
Yang BY
Source :: Fitoterapia [Fitoterapia] 2024 Apr; Vol. 174, pp. 105876. Date of Electronic Publication: 2024 Feb 29.
Publication Year :: 2024
Abstract: Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4 <superscript>+</superscript> probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC <subscript>50</subscript> value of 11.66 μM against HEPG2.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.<br /> (Copyright © 2023. Published by Elsevier B.V.)