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A Nanographene-Porphyrin Hybrid for Near-Infrared-Ii Phototheranostics.
- Source :
-
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 May; Vol. 11 (18), pp. e2309131. Date of Electronic Publication: 2024 Mar 02. - Publication Year :
- 2024
-
Abstract
- Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) in the second near-infrared (NIR-II, 1000-1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that the π-extended porphyrins fused with one or two nanographene units (NGP-1 and NGP-2) can serve as a new class of NIR-responsive organic agents, displaying absorption extending to ≈1000 and ≈1400 nm in the NIR-I and NIR-II windows, respectively. NGP-1 and NGP-2 are dispersed in water through encapsulation into self-assembled nanoparticles (NPs), achieving high photothermal conversion efficiency of 60% and 69%, respectively, under 808 and 1064 nm laser irradiation. Moreover, the NIR-II-active NGP-2-NPs demonstrated promising photoacoustic responses, along with high photostability and biocompatibility, enabling PAI and efficient NIR-II PTT of cancer in vivo.<br /> (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
- Subjects :
- Mice
Animals
Nanoparticles chemistry
Nanoparticles therapeutic use
Graphite chemistry
Humans
Infrared Rays
Disease Models, Animal
Photothermal Therapy methods
Cell Line, Tumor
Neoplasms therapy
Phototherapy methods
Porphyrins chemistry
Theranostic Nanomedicine methods
Photoacoustic Techniques methods
Subjects
Details
- Language :
- English
- ISSN :
- 2198-3844
- Volume :
- 11
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 38430537
- Full Text :
- https://doi.org/10.1002/advs.202309131