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Fat malabsorption in short bowel syndrome: A review of pathophysiology and management.
- Source :
-
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2024 Apr; Vol. 39 Suppl 1, pp. S17-S28. - Publication Year :
- 2024
-
Abstract
- Fat malabsorption is central to the pathophysiology of short bowel syndrome (SBS). It occurs in patients with insufficient intestinal surface area and/or function to maintain metabolic and growth demands. Rapid intestinal transit and impaired bile acid recycling further contribute to fat malabsorption. A significant portion of patients require parenteral nutrition (PN) for their survival but may develop sepsis and liver dysfunction as a result. Despite advancements in the treatment of SBS, fat malabsorption remains a chronic issue for this vulnerable patient population. Peer-reviewed literature was assessed on the topic of fat malabsorption in SBS. Current management of patients with SBS involves dietary considerations, PN management, antidiarrheals, glucagon-like peptide 2 agonists, and multidisciplinary teams. Clinical trials have focused on improving intestinal fat absorption by facilitating fat digestion with pancreatic enzymes. Targeting fat malabsorption in SBS is a potential pathway to improving lifestyle and reducing morbidity and mortality in this rare disease.<br /> (© 2024 American Society for Parenteral and Enteral Nutrition.)
Details
- Language :
- English
- ISSN :
- 1941-2452
- Volume :
- 39 Suppl 1
- Database :
- MEDLINE
- Journal :
- Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 38429962
- Full Text :
- https://doi.org/10.1002/ncp.11119