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Differential effects of antiseizure medications on neurogenesis: Evidence from cells to animals.

Authors :
Alavi MS
Al-Asady AM
Fanoudi S
Sadeghnia HR
Source :
Heliyon [Heliyon] 2024 Feb 17; Vol. 10 (4), pp. e26650. Date of Electronic Publication: 2024 Feb 17 (Print Publication: 2024).
Publication Year :
2024

Abstract

Neurogenesis, the process of generating functionally integrated neurons from neural stem and progenitor cells, is involved in brain development during embryonic stages but continues throughout life. Adult neurogenesis plays essential roles in many brain functions such as cognition, brain plasticity, and repair. Abnormalities in neurogenesis have been described in many neuropsychiatric and neurological disorders, including epilepsy. While sharing a common property of suppressing seizures, accumulating evidence has shown that some antiseizure medications (ASM) exhibit neuroprotective potential in the non-epileptic models including Parkinson's disease, Alzheimer's disease, cerebral ischemia, or traumatic brain injury. ASM are a heterogeneous group of medications with different mechanisms of actions. Therefore, it remains to be revealed whether neurogenesis is a class effect or related to them all. In this comprehensive literature study, we reviewed the literature data on the influence of ASM on the neurogenesis process during brain development and also in the adult brain under physiological or pathological conditions. Meanwhile, we discussed the underlying mechanisms associated with the neurogenic effects of ASM by linking the reported in vivo and in vitro studies. PubMed, Web of Science, and Google Scholar databases were searched until the end of February 2023. A total of 83 studies were used finally. ASM can modulate neurogenesis through the increase or decrease of proliferation, survival, and differentiation of the quiescent NSC pool. The present article indicated that the neurogenic potential of ASM depends on the administered dose, treatment period, temporal administration of the drug, and normal or disease context.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2024 The Authors.)

Details

Language :
English
ISSN :
2405-8440
Volume :
10
Issue :
4
Database :
MEDLINE
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
38420427
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e26650