Evaluating the performance of OCT in assessing static and potential dynamic properties of the retinal ganglion cells and nerve fiber bundles in the living mouse eye.

Authors :: Zhang P
Vafaeva O
Dolf C
Ma Y
Wang G
Cho J
Chan HH
Marsh-Armstrong N
Zawadzki RJ
Source :: Biomedical optics express [Biomed Opt Express] 2023 Nov 28; Vol. 14 (12), pp. 6422-6441. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Glaucoma is a group of eye diseases characterized by the thinning of the retinal nerve fiber layer (RNFL), which is primarily caused by the progressive death of retinal ganglion cells (RGCs). Precise monitoring of these changes at a cellular resolution in living eyes is significant for glaucoma research. In this study, we aimed to assess the effectiveness of temporal speckle averaging optical coherence tomography (TSA-OCT) and dynamic OCT (dOCT) in examining the static and potential dynamic properties of RGCs and RNFL in living mouse eyes. We evaluated parameters such as RNFL thickness and possible dynamics, as well as compared the ganglion cell layer (GCL) soma density obtained from in vivo OCT, fluorescence scanning laser ophthalmoscopy (SLO), and ex vivo histology.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (© 2023 Optica Publishing Group.)

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