All That Is Small Is Not a Small-Cell Carcinoma: Thoracic SMARCA4-Deficient Undifferentiated Tumors Masquerading as SCLC.

Authors :: Rekhtman N
Source :: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 May 01; Vol. 30 (9), pp. 1708-1711.
Publication Year :: 2024
Abstract: Small-cell lung carcinoma (SCLC) cell lines have been widely utilized as a preclinical model of this highly aggressive disease. However, since their creation decades ago, novel tumor entities have been defined that might clinicopathologically mimic SCLC, which notably includes thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT). Multiomic reassessment of the presumed SCLC cell lines with high YAP1 expression reveals that nearly all of these tumors represent unsuspected SMARCA4-UT. See related article by Ng et al., p. 1846.<br /> (©2024 American Association for Cancer Research.)

Subjects :: Humans
Diagnosis, Differential
Thoracic Neoplasms diagnosis
Thoracic Neoplasms genetics
Thoracic Neoplasms pathology
Cell Line, Tumor
DNA Helicases genetics
DNA Helicases deficiency
Small Cell Lung Carcinoma diagnosis
Small Cell Lung Carcinoma genetics
Small Cell Lung Carcinoma pathology
Transcription Factors genetics
Transcription Factors deficiency
Nuclear Proteins genetics
Nuclear Proteins deficiency
Lung Neoplasms diagnosis
Lung Neoplasms genetics
Lung Neoplasms pathology

Language :: English
ISSN :: 1557-3265
Volume :: 30
Issue :: 9
Database :: MEDLINE
Journal :: Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Type :: Academic Journal
Accession number :: 38416596
Full Text :: https://doi.org/10.1158/1078-0432.CCR-24-0227

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