Start Over

Dereplication of calystegines in food plants and wild Solanum Brazilian fruits.

Authors :: Souto LFL
Borges RM
da Costa RG
Dos Santos RIL
da Silva AJR
Source :: Food chemistry [Food Chem] 2024 Jul 15; Vol. 446, pp. 138808. Date of Electronic Publication: 2024 Feb 22.
Publication Year :: 2024
Abstract: Calystegines are potent glycosidase inhibitors with therapeutic potential and are constituents of food and feed with potential toxic effects. This study aims to target calystegines and other nitrogenous substances in food plants. Hydroalcoholic extracts from Solanum tuberosum, Ipomoea batatas, S. lycocarpum, and fruit from S. lycopersicum, S. aethiopicum, S. paniculatum, S. crinitum, and S. acanthodes were analyzed by liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) using an acidic HILIC column. The dereplication approach included data processing using MZMine2, FBMN-GNPS, and structure elucidation and interpretation of the organized data. The calystegines A <subscript>3</subscript> , A <subscript>5</subscript> , B <subscript>2</subscript> , and C <subscript>1</subscript> were identified, and several potential new calystegine analogues: three may correspond to new calystegines of the A-group, one glycosyl derivative of calystegine A <subscript>3</subscript> , and two glycosyl derivatives of the B-group. These findings help to direct the search for new calystegines. In addition, the dereplication approach enabled the annotation of 22 other nitrogen compounds.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)