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Characterization of the Newborn Epidermis and Adult Hair Follicles Using Whole-Mount Immunofluorescent Staining of Mouse Dorsal Skin.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2849, pp. 45-54. - Publication Year :
- 2024
-
Abstract
- The mammalian integumentary system, including skin and its appendages, serves as a protective barrier for the body. During development, skin epidermis undergoes rapid cell division and differentiation to form multiple stratified layers of keratinocytes. Concurrently the epidermis also gives rise to hair follicles that invaginate into the dermis. In adult skin, the hair follicle undergoes cyclic regeneration fueled by hair follicle stem cells located in the bulge. Three-dimensional and high-resolution imaging of these structures using whole-mount immunofluorescent staining allows to better characterize epidermal progenitors and stem cells.<br /> (© 2024. Springer Science+Business Media, LLC.)
- Subjects :
- Animals
Mice
Animals, Newborn
Staining and Labeling methods
Skin cytology
Skin metabolism
Epidermal Cells cytology
Epidermal Cells metabolism
Stem Cells cytology
Stem Cells metabolism
Keratinocytes cytology
Keratinocytes metabolism
Hair Follicle cytology
Hair Follicle metabolism
Epidermis metabolism
Fluorescent Antibody Technique methods
Subjects
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 2849
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 38407797
- Full Text :
- https://doi.org/10.1007/7651_2024_513