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Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications.

Authors :
Zhang Y
Huang K
Duan J
Zhao R
Yang L
Source :
Psychopharmacology [Psychopharmacology (Berl)] 2024 Apr; Vol. 241 (4), pp. 637-651. Date of Electronic Publication: 2024 Feb 26.
Publication Year :
2024

Abstract

Nowadays, high morbidity and mortality of cardiovascular diseases (CVDs) and high comorbidity rate of neuropsychiatric disorders contribute to global burden of health and economics. Consequently, a discipline concerning abnormal connections between the brain and the heart and the resulting disease states, known as psychocardiology, has garnered interest among researchers. However, identifying a common pathway that physicians can modulate remains a challenge. Gut microbiota, a constituent part of the human intestinal ecosystem, is likely involved in mutual mechanism CVDs and neuropsychiatric disorder share, which could be a potential target of interventions in psychocardiology. This review aimed to discuss complex interactions from the perspectives of microbial and intestinal dysfunction, behavioral factors, and pathophysiological changes and to present possible approaches to regulating gut microbiota, both of which are future directions in psychocardiology.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Details

Language :
English
ISSN :
1432-2072
Volume :
241
Issue :
4
Database :
MEDLINE
Journal :
Psychopharmacology
Publication Type :
Academic Journal
Accession number :
38407637
Full Text :
https://doi.org/10.1007/s00213-024-06552-6