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Development and Internal Validation of a Model for Predicting Overall Survival in Subjects with MAFLD: A Cohort Study.
- Source :
-
Journal of clinical medicine [J Clin Med] 2024 Feb 19; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 19. - Publication Year :
- 2024
-
Abstract
- Background & Aims : Fatty liver disease with metabolic dysfunction (MAFLD) is a new concept proposed to replace the previous concept of Non-Alcoholic Hepatic Steatosis (NAFLD). We developed and internally validated a prognostic model to predict the likelihood of death in a cohort of subjects with MAFLD. Methods: Our work involved two steps: the first was the construction of a bootstrapped multivariable Cox model for mortality risk prognosis and the second was its validation. Results: The study cohort included 1506 subjects, of which 907 were used for internal validation. Discriminant measures for the final model were R <superscript>2</superscript> <subscript>D</subscript> 0.6845 and Harrell's C 0.8422 in the development and R <superscript>2</superscript> <subscript>D</subscript> 0.6930 and Harrell's C 0.8465 in the validation. We used the nine independent prognostic factors selected by the LASSO Cox procedure and fitted by the bootstrap Cox survival model, and observed β were: Gender 0.356 1.42 ( p < 0.008), Age 0.146 ( p < 0.001), Glycemia 0.004 ( p < 0.002), Total Cholesterol -0.0040 ( p < 0.009), Gamma Glutamyl Transpeptidase 0.009 ( p < 0.001), SBP 0.009 ( p < 0.036), DBP -0.016 ( p < 0.041), ALP 0.008 ( p < 0.071) and Widowhood 0.550 ( p < 0.001). Conclusions: We produced and validated a model to estimate the probability of death in subjects with MAFLD. The instruments we used showed satisfactory predictive capabilities.
Details
- Language :
- English
- ISSN :
- 2077-0383
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38398493
- Full Text :
- https://doi.org/10.3390/jcm13041181