Back to Search
Start Over
PLA2R-positive membranous nephropathy in IgG4-related disease.
- Source :
-
BMC nephrology [BMC Nephrol] 2024 Feb 23; Vol. 25 (1), pp. 66. Date of Electronic Publication: 2024 Feb 23. - Publication Year :
- 2024
-
Abstract
- Background: IgG4-related disease (IgG4-RD) is a fibroinflammatory disease that affects multiple organs, including the pancreas, lacrimal glands, salivary glands, periaortic/retroperitoneum, and kidney. Interstitial nephritis is a typical renal disorder associated with IgG4-RD, but membranous nephropathy is also seen in some cases.<br />Case Presentation: Herein we report on the case of a 77-year-old male patient with nephrotic syndrome and IgG4-related lung disease. His serum phospholipase A2 receptor (PLA2R) antibody was positive. His renal biopsy specimen was also positive for PLA2R. The renal biopsy specimen showed membranous nephropathy with equal IgG3 and IgG4 immunofluorescence staining and no interstitial nephritis, suggesting IgG4-RD manifesting as membranous nephropathy.<br />Conclusions: Nephrotic syndrome caused by membranous nephropathy is sometimes associated with IgG4-RD. In such cases, even if serum PLA2R antibody is positive, it should be considered that the membranous nephropathy may be secondary to IgG4-RD.<br /> (© 2024. The Author(s).)
- Subjects :
- Male
Humans
Aged
Receptors, Phospholipase A2
Immunoglobulin G
Autoantibodies
Glomerulonephritis, Membranous complications
Glomerulonephritis, Membranous diagnosis
Immunoglobulin G4-Related Disease complications
Immunoglobulin G4-Related Disease diagnosis
Nephrotic Syndrome complications
Nephritis, Interstitial complications
Nephritis, Interstitial diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2369
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 38395839
- Full Text :
- https://doi.org/10.1186/s12882-024-03511-3