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Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease: a longitudinal prospective study.

Authors :
da Silva MO
do Carmo Chaves AEC
Gobbato GC
Lavinsky F
Lavinsky D
Source :
BMC ophthalmology [BMC Ophthalmol] 2024 Feb 23; Vol. 24 (1), pp. 85. Date of Electronic Publication: 2024 Feb 23.
Publication Year :
2024

Abstract

Background: To evaluate structural changes in retina and choroid in patients with type 2 diabetes (T2D) and their association with diabetic kidney disease (DKD).<br />Methods: T2D patients with mild or no diabetic retinopathy (DR) were followed for 3 years using structural SS-OCT and OCT angiography (OCT-A) taken every 6 months. Parameters were compared longitudinally and according to the DKD status on baseline.<br />Results: One hundred and sixty eyes from 80 patients were followed for 3 years, 72 with no DKD (nDKD) at baseline and 88 with DKD. Trend analysis of T2D showed significant thinning in GCL + and circumpapillary retinal fiber neural layer (cRFNL), choroid, and decreased vascular density (VD) in superficial plexus and central choriocapillaris with foveal avascular zone (FAZ) enlargement. Patients with no DKD on baseline presented more significant declines in retinal center and choroidal thickness, increased FAZ and loss of nasal and temporal choriocapillaris volume. In addition, the nDKD group had worse glycemic control and renal parameters at the end of the study.<br />Conclusion: Our data suggests the potential existence of early and progressive neurovascular damage in the retina and choroid of patients with Type 2 Diabetes (T2D) who have either no or mild Diabetic Retinopathy (DR). The progression of neurovascular damage appears to be correlated with parameters related to glycemic control and renal damage.<br /> (© 2024. The Author(s).)

Details

Language :
English
ISSN :
1471-2415
Volume :
24
Issue :
1
Database :
MEDLINE
Journal :
BMC ophthalmology
Publication Type :
Academic Journal
Accession number :
38395808
Full Text :
https://doi.org/10.1186/s12886-024-03346-4