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Slc43a2 + T cell metastasis from spleen to brain in RGNNV infected teleost.
- Source :
-
Science China. Life sciences [Sci China Life Sci] 2024 Apr; Vol. 67 (4), pp. 733-744. Date of Electronic Publication: 2024 Feb 21. - Publication Year :
- 2024
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Abstract
- The origin of T cells in the teleost's brain is unclear. While viewing the central nervous system (CNS) as immune privileged has been widely accepted, previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral organs. Here, we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper (Epinephelus coioices) through single-cell RNA-sequencing analysis. After viral CNS infection with red-spotted grouper nervous necrosis virus (RGNNV), the number of slc43a2 <superscript>+</superscript> T cells synchronously increased in the spleen and brain. During the infection tests in asplenic zebrafish (tlx1 <superscript>▲</superscript> zebrafish model), no increase in the number of slc43a2 <superscript>+</superscript> T cells was observed in the brain. Single-cell transcriptomic analysis indicated that slc43a2 <superscript>+</superscript> T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune response. This study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.<br /> (© 2024. Science China Press.)
Details
- Language :
- English
- ISSN :
- 1869-1889
- Volume :
- 67
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Science China. Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38388846
- Full Text :
- https://doi.org/10.1007/s11427-023-2473-x