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Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI.

Authors :
Screven LA
Pantazis CB
Andersh KM
Hong S
Vitale D
Lara E
Ku RY
Heutink P
Meyer J
Faber K
Nho K
Saykin AJ
Foroud TM
Nalls MA
Blauwendraat C
Singleton A
Narayan PS
Source :
Neuron [Neuron] 2024 Mar 06; Vol. 112 (5), pp. 694-697. Date of Electronic Publication: 2024 Feb 21.
Publication Year :
2024

Abstract

The iDA Project (iPSCs to Study Diversity in Alzheimer's and Alzheimer's Disease-related Dementias) is generating 200 induced pluripotent stem cell lines from Alzheimer's Disease Neuroimaging Initiative participants. These lines are sex balanced, include common APOE genotypes, span disease stages, and are ancestrally diverse. Cell lines and characterization data will be shared openly.<br />Competing Interests: Declaration of interests A.J.S. has received support from Avid Radiopharmaceuticals, a subsidiary of Eli Lilly (in-kind contribution of PET tracer precursor), and has participated in scientific advisory boards (Bayer Oncology, Eisai, Novo Nordisk, and Siemens Medical Solutions USA, Inc) and an observational study monitoring board (MESA, NIH NHLBI). He also serves as editor-in-chief for Brain Imaging and Behavior, a Springer-Nature journal, and serves on four other NIA external advisory committees. M.A.N. currently serves on the scientific advisory board for Character Bio Inc. and is a scientific founder at Neuron23 Inc.<br /> (Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1097-4199
Volume :
112
Issue :
5
Database :
MEDLINE
Journal :
Neuron
Publication Type :
Academic Journal
Accession number :
38387456
Full Text :
https://doi.org/10.1016/j.neuron.2024.01.026