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Intravenous tranexamic acid reduces complications following surgical treatment of pathologic fractures of the lower extremity.
- Source :
-
Journal of surgical oncology [J Surg Oncol] 2024 May; Vol. 129 (6), pp. 1150-1158. Date of Electronic Publication: 2024 Feb 22. - Publication Year :
- 2024
-
Abstract
- Background and Objectives: This study aimed to evaluate the postoperative complications associated with administering intravenous (IV) tranexamic acid (TXA) in patients undergoing surgical fixation for neoplastic pathologic fractures of the lower extremities.<br />Methods: Patients ≥18 years old who underwent surgical intervention for neoplastic pathologic lower extremity fractures from 2015 to 2021 were identified using the Premier Healthcare Database. This cohort was divided by TXA receipt on the index surgery day. Patient demographics, hospital factors, patient comorbidities, and 90-day complications were assessed and compared between the cohorts.<br />Results: From 2015 to 2021, 4497 patients met inclusion criteria (769 TXA[+] and 3728 TXA[-]). Following propensity score matching, patients who received TXA had a significantly shorter length of stay than those who did not (7.6 ± 7.3 days vs. 9.0 ± 15.2, p = 0.036). Between the two cohorts, there were no significant differences in comorbidities. Regarding differences in postoperative complications, TXA(+) patients had significantly decreased odds of deep vein thrombosis (DVT) (1.87% vs. 5.46%; odds ratio [OR]:0.33; 95% confidence interval: 0.17-0.62; p = 0.001).<br />Conclusion: Administration of IV TXA may be associated with a decreased risk of postoperative DVT without an increased risk of other complications. Orthopedic surgeons should consider the utilization of IV TXA in patients treated surgically for neoplastic pathologic fractures of the lower extremity.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Humans
Male
Female
Middle Aged
Retrospective Studies
Aged
Fractures, Spontaneous prevention & control
Fractures, Spontaneous surgery
Fractures, Spontaneous etiology
Administration, Intravenous
Lower Extremity surgery
Follow-Up Studies
Adult
Prognosis
Tranexamic Acid administration & dosage
Antifibrinolytic Agents administration & dosage
Postoperative Complications prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9098
- Volume :
- 129
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38385654
- Full Text :
- https://doi.org/10.1002/jso.27601