Coarse Particulate Matter and Markers of Inflammation and Coagulation in the Multi-Ethnic Study of Atherosclerosis (MESA) Population: A Repeat Measures Analysis.

Background: In contrast to fine particles, less is known of the inflammatory and coagulation impacts of coarse particulate matter ( PM 10 - 2.5 , particulate matter with aerodynamic diameter ≤ 10 μ m  and > 2.5 μ m ). Toxicological research suggests that these pathways might be important processes by which PM 10 - 2.5 impacts health, but there are relatively few epidemiological studies due to a lack of a national PM 10 - 2.5 monitoring network.
Objectives: We used new spatiotemporal exposure models to examine associations of both 1-y and 1-month average PM 10 - 2.5 concentrations with markers of inflammation and coagulation.
Methods: We leveraged data from 7,071 Multi-Ethnic Study of Atherosclerosis and ancillary study participants 45-84 y of age who had repeated plasma measures of inflammatory and coagulation biomarkers. We estimated PM 10 - 2.5 at participant addresses 1 y and 1 month before each of up to four exams (2000-2012) using spatiotemporal models that incorporated satellite, regulatory monitoring, and local geographic data and accounted for spatial correlation. We used random effects models to estimate associations with interleukin-6 (IL-6), C-reactive protein (CRP), fibrinogen, and D-dimer, controlling for potential confounders.
Results: Increases in PM 10 - 2.5 were not associated with greater levels of inflammation or coagulation. A 10 - μ g / m 3 increase in annual average PM 10 - 2.5 was associated with a 2.5% decrease in CRP [95% confidence interval (CI): - 5.5 , 0.6]. We saw no association between annual average PM 10 - 2.5 and the other markers (IL-6: - 0.7 % , 95% CI: - 2.6 , 1.2; fibrinogen: - 0.3 % , 95% CI: - 0.9 , 0.3; D-dimer: - 0.2 % , 95% CI: - 2.6 , 2.4). Associations consistently showed that a 1 0 - μ g / m 3 increase in 1-month average PM 10 - 2.5 was associated with reduced inflammation and coagulation, though none were distinguishable from no association (IL-6: - 1.2 % , 95% CI: - 3.0   , 0.5; CRP: - 2.5 % , 95% CI: - 5.3 , 0.4; fibrinogen: - 0.4 % , 95% CI: - 1.0 , 0.1; D-dimer: - 2.0 % , 95% CI: - 4.3 , 0.3).
Discussion: We found no evidence that PM 10 - 2.5 is associated with higher inflammation or coagulation levels. More research is needed to determine whether the inflammation and coagulation pathways are as important in explaining observed PM 10 - 2.5 health impacts in humans as they have been shown to be in toxicology studies or whether PM 10 - 2.5 might impact human health through alternative biological mechanisms. https://doi.org/10.1289/EHP12972.