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Piezo channels in the intestinal tract.

Piezo channels in the intestinal tract.

Authors :
He H
Zhou J
Xu X
Zhou P
Zhong H
Liu M
Source :
Frontiers in physiology [Front Physiol] 2024 Feb 06; Vol. 15, pp. 1356317. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024).
Publication Year :
2024

Abstract

The intestine is the largest mechanosensitive organ in the human body whose epithelial cells, smooth muscle cells, neurons and enteroendocrine cells must sense and respond to various mechanical stimuli such as motility, distension, stretch and shear to regulate physiological processes including digestion, absorption, secretion, motility and immunity. Piezo channels are a newly discovered class of mechanosensitive ion channels consisting of two subtypes, Piezo1 and Piezo2. Piezo channels are widely expressed in the intestine and are involved in physiological and pathological processes. The present review summarizes the current research progress on the expression, function and regulation of Piezo channels in the intestine, with the aim of providing a reference for the future development of therapeutic strategies targeting Piezo channels.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 He, Zhou, Xu, Zhou, Zhong and Liu.)

Details

Language :
English
ISSN :
1664-042X
Volume :
15
Database :
MEDLINE
Journal :
Frontiers in physiology
Publication Type :
Academic Journal
Accession number :
38379701
Full Text :
https://doi.org/10.3389/fphys.2024.1356317