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Novel Butenolide Derivatives as Dual-Chitinase Inhibitors to Arrest the Growth and Development of the Asian Corn Borer.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Mar 06; Vol. 72 (9), pp. 5036-5046. Date of Electronic Publication: 2024 Feb 20. - Publication Year :
- 2024
-
Abstract
- Of ChtI and Of Chi-h are considered potential targets for the control of Asian corn borer ( Ostrinia furnacalis ). In this work, the previously reported Of ChtI inhibitor 5f was found to show certain inhibitory activity against Of Chi-h ( K <subscript> i </subscript> = 5.81 μM). Two series of novel butenolide derivatives based on lead compound 5f were designed with the conjugate skeleton, contributing to the π-binding interaction to chitinase, and then synthesized. Compounds 4a-l and 7a-p displayed excellent inhibitory activities against Of ChtI and Of Chi-h, respectively, at a concentration of 10 μM. Compound 4h was found to be a good dual-Chitinase inhibitor, with K <subscript>i</subscript> values of 1.82 and 2.00 μM against Of ChtI and Of Chi-h, respectively. The inhibitory mechanism studies by molecular docking suggested that π-π stacking interactions were crucial to the inhibitory activity of novel butenolide derivatives against two different chitinases. A preliminary bioassay indicated that 4h exhibited certain growth inhibition effects against O. furnacalis . Butenolide-like analogues should be further studied as promising novel dual-chitinase inhibitor candidates for the control of O. furnacalis .
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 72
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38377548
- Full Text :
- https://doi.org/10.1021/acs.jafc.3c06714