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Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial.

Authors :
Hites M
Massonnaud CR
Lapique EL
Belhadi D
Jamard S
Goehringer F
Danion F
Reignier J
de Castro N
Garot D
Lacombe K
Tolsma V
Faure E
Malvy D
Staub T
Courjon J
Cazenave-Roblot F
Dyrhol Riise AM
Leturnier P
Martin-Blondel G
Roger C
Akinosoglou K
Moing VL
Piroth L
Sellier P
Lescure X
Trøseid M
Clevenbergh P
Dalgard O
Gallien S
Gousseff M
Loubet P
Vardon-Bounes F
Visée C
Belkhir L
Botelho-Nevers É
Cabié A
Kotanidou A
Lanternier F
Rouveix-Nordon E
Silva S
Thiery G
Poignard P
Carcelain G
Diallo A
Mercier N
Terzic V
Bouscambert-Duchamp M
Gaymard A
Trabaud MA
Destras G
Josset L
Billard N
Han TH
Guedj J
Couffin-Cadiergues S
Dechanet A
Delmas C
Esperou H
Fougerou-Leurent C
Mestre SL
Métois A
Noret M
Bally I
Dergan-Dylon S
Tubiana S
Kalif O
Bergaud N
Leveau B
Eustace J
Greil R
Hajdu E
Halanova M
Paiva JA
Piekarska A
Rodriguez Baño J
Tonby K
Trojánek M
Tsiodras S
Unal S
Burdet C
Costagliola D
Yazdanpanah Y
Peiffer-Smadja N
Mentré F
Ader F
Source :
The Journal of infection [J Infect] 2024 Mar; Vol. 88 (3), pp. 106120. Date of Electronic Publication: 2024 Feb 16.
Publication Year :
2024

Abstract

Competing Interests: Declaration of Competing Interest M.H. reports grants from The Belgian Center for Knowledge (KCE), the Fonds Erasme-COVID-Université Libre de Bruxelles and the EU-Horizon program, for the submitted work; and has received support for attending meetings from Pfizer; support for participation on an advisory board for therapeutics on COVID-19; and support for leadership for the Belgian guidelines on therapeutics for COVID-19 and acting as a treasurer for the Belgian Society of Clinical Microbiology and Infectious Diseases. R.G. reports consulting fees from Celgene, Novartis, Roche, Bristol Myers Squibb, Takeda, Abbvie, AstraZeneca, Janssen, Merck Sharp & Dohme, Merck, Gilead, and Daiichi Sankvo; lecture fees from Celgene, Roche, Merck, Takeda, AstraZeneca, Novartis, Amgen, Bristol Myers Squibb, Merck Sharp & Dohme, Sandoz, Abbvie, Gilead, and Daiichi Sankvo; support for attending meetings from Roche, Amgen, Janssen, AstraZeneca, Novartis, Merck Sharp & Dohme, Celgene, Gilead, Bristol Myers Squibb, Abbvie, and Daiichi Sankvo; participation in a Data Safety and Monitoring Board for Celgene, Novartis, Roche, Bristol Myers Squibb, Takeda, Abbvie, AstraZeneca, Janssen, Merck Sharp & Dohme, Merck, Gilead, and Daiichi Sankyo; research grants from Celgene, Roche, Merck, Takeda, AstraZeneca, Novartis, Amgen, Bristol Myers Squibb, Merck Sharp & Dohme, Sandoz, Abbvie, Gilead, and Daiichi Sankyo. J.-A.P. reports consulting fees from Pfizer, Merck Sharp & Dohme, and Janssen-Cilag; lecture fees from Pfizer; and support for attending meetings from Pfizer. D.C. reports grants and lecture fees from Janssen and lecture fees from Gilead, outside the submitted work. C.B. reports participation in a Data Safety and Monitoring Board for 4Living Biotech; and consulting fees from Da Volterra and Mylan Pharmaceuticals, outside the submitted work. F.M. reports grants and consulting fees from Da Volterra, grants from Sanofi, and consulting fees from Ipsen, outside the submitted work. All other authors declare no competing interests.

Details

Language :
English
ISSN :
1532-2742
Volume :
88
Issue :
3
Database :
MEDLINE
Journal :
The Journal of infection
Publication Type :
Editorial & Opinion
Accession number :
38367705
Full Text :
https://doi.org/10.1016/j.jinf.2024.106120