Back to Search
Start Over
The role of chimeric antigen receptor T cells targeting more than one antigen in the treatment of B-cell malignancies.
- Source :
-
British journal of haematology [Br J Haematol] 2024 May; Vol. 204 (5), pp. 1649-1659. Date of Electronic Publication: 2024 Feb 16. - Publication Year :
- 2024
-
Abstract
- Several products containing chimeric antigen receptor T cells targeting CD19 (CART19) have been approved for the treatment of patients with relapsed/refractory non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukaemia (ALL). Despite very impressive response rates, a significant percentage of patients experience disease relapse and die of progressive disease. A major cause of CART19 failure is loss or downregulation of CD19 expression in tumour cells, which has prompted a myriad of novel strategies aimed at targeting more than one antigen (e.g. CD19 and CD20 or CD22). Dual targeting can the accomplished through co-administration of two separate products, co-transduction with two different vectors, bicistronic cassettes or tandem receptors. In this manuscript, we review the pros and cons of each strategy and the clinical results obtained so far.<br /> (© 2024 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
- Subjects :
- Humans
Lymphoma, B-Cell therapy
Lymphoma, B-Cell immunology
Receptors, Antigen, T-Cell genetics
T-Lymphocytes immunology
T-Lymphocytes metabolism
Antigens, CD20 immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology
Antigens, Neoplasm immunology
Sialic Acid Binding Ig-like Lectin 2 immunology
Receptors, Chimeric Antigen immunology
Immunotherapy, Adoptive methods
Antigens, CD19 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 204
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 38362778
- Full Text :
- https://doi.org/10.1111/bjh.19348