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Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study.
- Source :
-
Internal and emergency medicine [Intern Emerg Med] 2024 Apr; Vol. 19 (3), pp. 689-696. Date of Electronic Publication: 2024 Feb 14. - Publication Year :
- 2024
-
Abstract
- The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI-Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65-0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52-0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions.<br /> (© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)
- Subjects :
- Humans
Aged
Male
Retrospective Studies
Female
Aged, 80 and over
Italy epidemiology
Cohort Studies
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Angiotensin-Converting Enzyme Inhibitors adverse effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Pneumonia drug therapy
Angiotensin Receptor Antagonists therapeutic use
Angiotensin Receptor Antagonists adverse effects
Hospitalization statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1970-9366
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Internal and emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38353881
- Full Text :
- https://doi.org/10.1007/s11739-023-03528-w