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Comparison of postoperative survival between early-onset and late-onset adenocarcinoma of esophagogastric junction: a population-based study.
- Source :
-
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2024 Jun; Vol. 39 (6), pp. 1073-1081. Date of Electronic Publication: 2024 Feb 14. - Publication Year :
- 2024
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Abstract
- Background and Aim: The prognosis of early-onset adenocarcinoma of esophagogastric junction (AEG) remains unclear. This research aimed at comparing the prognosis between early-onset and late-onset AEGs.<br />Methods: We extracted eligible patients with surgically resected, pathologically confirmed, nonmetastatic AEG from the Surveillance, Epidemiology, and End Results database from 2004 to 2015. The cutoff age of early-onset AEG was set at ≤50 years old. Univariate and multivariate Cox analysis as well as competing risk model were adopted for comparing overall survival (OS) and cancer-specific survival (CSS) between early-onset and late-onset AEGs. In addition, multiple imputation and propensity score matching (PSM) were also carried out for sensitivity analysis.<br />Results: In total, 4610 eligible AEG patients were collected in this study, including 610 early-onset AEGs and 4000 late-onset AEGs. Kaplan-Meier curves revealed significantly better survival in early-onset AEGs than late-onset AEGs. After interpolating missing data by multiple imputation, multivariate Cox regression analysis similarly showed better OS and CSS in early-onset AEGs. By using PSM analysis at a ratio of 1:1, we matched 610 early-onset AEG patients with 610 late-onset AEG patients. After PSM, univariate Cox regression model still revealed favorable prognosis in early-onset AEGs. Similar results were confirmed by performing PSM analysis at a ratio of 1:2 and 1:3. In addition, competing risk model demonstrated significantly lower cancer-specific death in early-onset AEGs compared to late-onset AEGs before and after matching.<br />Conclusion: By applying several effective sensitivity analyses, we reported significantly favorable OS and CSS in early-onset AEGs compared to late-onset AEGs.<br /> (© 2024 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Humans
Middle Aged
Male
Female
Prognosis
Stomach Neoplasms mortality
Stomach Neoplasms surgery
Stomach Neoplasms pathology
Age of Onset
Survival Rate
Proportional Hazards Models
Aged
Time Factors
Adult
Age Factors
SEER Program
Kaplan-Meier Estimate
Esophagogastric Junction surgery
Esophagogastric Junction pathology
Adenocarcinoma mortality
Adenocarcinoma surgery
Adenocarcinoma pathology
Esophageal Neoplasms mortality
Esophageal Neoplasms surgery
Esophageal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1746
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 38353050
- Full Text :
- https://doi.org/10.1111/jgh.16514