Back to Search
Start Over
Impact of active surveillance and decolonization strategies for methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 May; Vol. 44 (5), pp. 724-730. Date of Electronic Publication: 2024 Feb 13. - Publication Year :
- 2024
-
Abstract
- Objective: To assess the impact of active surveillance and decolonization strategies on methicillin-resistant Staphylococcus aureus (MRSA) infection rates in a NICU.<br />Study Design: MRSA infection rates were compared before (2014-2016) and during (2017-2022) an active surveillance program. Eligible infants were decolonized with chlorohexidine gluconate (CHG) bathing and/or topical mupirocin. Successful decolonization and rates of recolonization were assessed.<br />Results: Fifty-two (0.57%) of 9 100 hospitalized infants had invasive MRSA infections from 2014 to 2022; infection rates declined non-significantly. During the 6-year surveillance program, the risk of infection was 16.9-times [CI <subscript>95</subscript> 8.4, 34.1] higher in colonized infants than uncolonized infants. Those colonized with mupirocin-susceptible MRSA were more likely successfully decolonized (aOR 9.7 [CI <subscript>95</subscript> 4.2, 22.5]). Of 57 infants successfully decolonized who remained hospitalized, 34 (60%) became recolonized.<br />Conclusions: MRSA infection rates did not significantly decline in association with an active surveillance and decolonization program. Alternatives to mupirocin and CHG are needed to facilitate decolonization.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
- Subjects :
- Humans
Infant, Newborn
Female
Male
Anti-Infective Agents, Local administration & dosage
Anti-Infective Agents, Local therapeutic use
Baths
Methicillin-Resistant Staphylococcus aureus isolation & purification
Staphylococcal Infections prevention & control
Staphylococcal Infections drug therapy
Intensive Care Units, Neonatal
Mupirocin administration & dosage
Mupirocin therapeutic use
Chlorhexidine analogs & derivatives
Chlorhexidine administration & dosage
Chlorhexidine therapeutic use
Anti-Bacterial Agents therapeutic use
Anti-Bacterial Agents administration & dosage
Cross Infection prevention & control
Cross Infection epidemiology
Cross Infection microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 44
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 38351274
- Full Text :
- https://doi.org/10.1038/s41372-024-01902-w