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Comorbidities in COPD: Current and Future Treatment Challenges.

Authors :
Mariniello DF
D'Agnano V
Cennamo D
Conte S
Quarcio G
Notizia L
Pagliaro R
Schiattarella A
Salvi R
Bianco A
Perrotta F
Source :
Journal of clinical medicine [J Clin Med] 2024 Jan 27; Vol. 13 (3). Date of Electronic Publication: 2024 Jan 27.
Publication Year :
2024

Abstract

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition, primarily characterized by the presence of a limited airflow, due to abnormalities of the airways and/or alveoli, that often coexists with other chronic diseases such as lung cancer, cardiovascular diseases, and metabolic disorders. Comorbidities are known to pose a challenge in the assessment and effective management of COPD and are also acknowledged to have an important health and economic burden. Local and systemic inflammation have been proposed as having a potential role in explaining the association between COPD and these comorbidities. Considering that the number of patients with COPD is expected to rise, understanding the mechanisms linking COPD with its comorbidities may help to identify new targets for therapeutic purposes based on multi-dimensional assessments.

Details

Language :
English
ISSN :
2077-0383
Volume :
13
Issue :
3
Database :
MEDLINE
Journal :
Journal of clinical medicine
Publication Type :
Academic Journal
Accession number :
38337438
Full Text :
https://doi.org/10.3390/jcm13030743