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Generation of induced pluripotent stem cells (ZZUCSBi001-A) from skin fibroblasts of a healthy donor.

Authors :
Li SA
Zhang YJ
Zhu YQ
Meng XY
Chen CL
Liu PP
Sun W
Source :
Stem cell research [Stem Cell Res] 2024 Apr; Vol. 76, pp. 103328. Date of Electronic Publication: 2024 Feb 05.
Publication Year :
2024

Abstract

Fibroblasts were extracted from the scalp of a healthy 55-year-old male and subsequently transformed into pluripotent stem cells by introducing episomal plasmids harboring essential reprogramming factors. These induced pluripotent stem cells exhibited a normal karyotype and demonstrated the capacity to differentiate into all three germ layers, as confirmed through teratoma assays. This specific cell line serves as a valuable reference for comparative investigations alongside other induced pluripotent stem cell lines generated from somatic cells of patients afflicted by genetic neurodegenerative disorders.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1876-7753
Volume :
76
Database :
MEDLINE
Journal :
Stem cell research
Publication Type :
Academic Journal
Accession number :
38335661
Full Text :
https://doi.org/10.1016/j.scr.2024.103328