Back to Search
Start Over
Efficacy of a new water-free topical cyclosporine 0.1% solution for optimizing the ocular surface in patients with dry eye and cataract.
- Source :
-
Journal of cataract and refractive surgery [J Cataract Refract Surg] 2024 Jun 01; Vol. 50 (6), pp. 644-650. - Publication Year :
- 2024
-
Abstract
- This is a pooled analysis from 2 phase III clinical trials investigating a water-free topical cyclosporine 0.1% for the treatment of moderate to severe dry eye. The analyses included 1162 patients: 35% with cataract, 20% with pseudophakia, and 45% without cataract. Demographics or baseline characteristics were comparable across groups except for age and vision. The cyclosporine-treated patients achieved large mean improvements from baseline by day 15: -3.7 in patients without cataract, -3.2 in patients with cataract, and -3.1 in pseudophakic patients. These improvements were statistically significantly higher compared with the respective vehicle groups. In the cataract subgroup, 59% of patients treated with cyclosporine achieved ≥3 grade improvements in corneal staining score, as early as day 15. The magnitude of the effect and early onset of action make this new cyclosporine solution a promising candidate for preoperative management of ocular surface in patients undergoing cataract surgery.<br /> (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of ASCRS and ESCRS.)
- Subjects :
- Humans
Female
Male
Aged
Cataract complications
Middle Aged
Visual Acuity physiology
Double-Blind Method
Administration, Topical
Treatment Outcome
Cornea
Cyclosporine administration & dosage
Dry Eye Syndromes drug therapy
Ophthalmic Solutions administration & dosage
Immunosuppressive Agents administration & dosage
Pseudophakia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4502
- Volume :
- 50
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cataract and refractive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 38334413
- Full Text :
- https://doi.org/10.1097/j.jcrs.0000000000001423