Three new griseofulvin derivatives from Aureobasidium pullulans .

Three new griseofulvin derivatives, griseofulvinoside A-C ( 1 - 3 ), were isolated from the ethyl acetate extract of the solid fermentation product of Aureobasidium pullulans . Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR. The antifungal activities of new compounds were evaluated against four phytopathogenic fungi in vitro , and all test compounds demonstrated inhibitory effects. Among them, compound 2 exhibited the most potent activities against the four selected phytopathogenic fungi with inhibitory rates ranging from 40.2 to 75.8% at 0.2 mg/mL.