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Erythropoiesis and estimated fluid volume regulation following initiation of ipragliflozin treatment in patients with type 2 diabetes mellitus and chronic kidney disease: A post-hoc analysis of the PROCEED trial.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 May; Vol. 26 (5), pp. 1723-1730. Date of Electronic Publication: 2024 Feb 07. - Publication Year :
- 2024
-
Abstract
- Aims: To analyse the changes in erythropoietic and estimated fluid volume parameters after the initiation of ipragliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD).<br />Methods: This was a post-hoc analysis of the PROCEED trial, which evaluated the effect of 24-week ipragliflozin treatment on endothelial dysfunction in patients with T2DM and CKD. We evaluated the changes in erythropoietic and estimated fluid volume parameters from baseline to 24 weeks post-treatment in 53 patients who received ipragliflozin (ipragliflozin group) and 55 patients with T2DM and CKD without sodium-glucose co-transporter 2 inhibitors (control group), a full analysis set of the PROCEED trial.<br />Results: The increases in haemoglobin [estimated group difference, 0.5 g/dl; 95% confidence interval (CI), 0.3-0.8; p < .001], haematocrit (estimated group difference, 2.2%; 95% CI, 1.3-3.1; p < .001) and erythropoietin (estimated log-transformed group difference, 0.1; 95% CI, 0.01-0.3; p = .036) were significantly greater in the ipragliflozin group than those in the control group. Ipragliflozin treatment was significantly associated with an increase in erythropoietin, independent of the corresponding change in haemoglobin (β = 0.253, p < .001) or haematocrit (β = 0.278, p < .001). Reductions in estimated plasma volume (estimated group difference, -7.94%; 95% CI, -11.6 to -4.26%; p < .001) and estimated extracellular volume (estimated group difference, -181.6 ml; 95% CI, -275.7 to -87.48 ml; p < .001) were significantly greater in the ipragliflozin group than those in the control group.<br />Conclusions: Erythropoiesis was enhanced and estimated fluid volumes were reduced by ipragliflozin in patients with T2DM and CKD.<br />Clinical Trial: PROCEED trial (registration number: jRCTs071190054).<br /> (© 2024 John Wiley & Sons Ltd.)
- Subjects :
- Humans
Erythropoiesis
Glucose therapeutic use
Hemoglobins therapeutic use
Sodium
Hypoglycemic Agents therapeutic use
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Sodium-Glucose Transporter 2 Inhibitors adverse effects
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic drug therapy
Renal Insufficiency, Chronic chemically induced
Erythropoietin therapeutic use
Symporters therapeutic use
Glucosides
Thiophenes
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 26
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 38326092
- Full Text :
- https://doi.org/10.1111/dom.15481