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Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979-2022.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2024 Mar; Vol. 30 (3), pp. 432-443. Date of Electronic Publication: 2024 Feb 07. - Publication Year :
- 2024
-
Abstract
- During 1979-2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon.
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 38325363
- Full Text :
- https://doi.org/10.3201/eid3003.230861