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Bone protective effect of sinomenine against monosodium iodoacetate induced knee and hip injury in rat model: an inflammatory pathway.
- Source :
-
Acta cirurgica brasileira [Acta Cir Bras] 2024 Feb 05; Vol. 39, pp. e390924. Date of Electronic Publication: 2024 Feb 05 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Purpose: Osteoarthritis (OA) is a degenerative joint disease which is categorized via destruction of joint cartilage and it also affects the various joints, especially knees and hips. Sinomenine active phytoconstituents isolated from the stem of Sinomenium acutum and already proof anti-inflammatory effect against the arthritis model of rodent. In this experimental protocol, we scrutinized the anti-osteoarthritis effect of sinomenine against monosodium iodoacetate (MIA) induced OA in rats.<br />Methods: MIA (3 mg/50 μL) was used for inducing the OA in the rats, and rats received the oral administration of sinomenine (2.5, 5 and 7.5 mg/kg body weight) up to the end of the experimental study (four weeks). The body and organs weight were estimated. Aggrecan, C-terminal cross-linked telopeptide of type II collagen (CTX-II), glycosaminoglycans (GCGs), monocyte chemoattractant protein-1 (MCP-1), Interferon gamma (IFN-γ), antioxidant, inflammatory cytokines, inflammatory mediators and matrix metalloproteinases (MMP) were analyzed.<br />Results: Sinomenine significantly (P < 0.001) boosted the body weight and reduced the heart weight, but the weight of spleen and kidney remain unchanged. Sinomenine significantly (P < 0.001) reduced the level of nitric oxide, MCP-1 and improved the level of aggrecan, IFN-γ and GCGs. Sinomenine remarkably upregulated the level of glutathione, superoxide dismutase and suppressed the level of malonaldehyde. It effectually modulated the level of inflammatory cytokines and inflammatory mediators and significantly (P < 0.001) reduced the level of MMPs, like MMP-1, 2, 3, 9 and 13.<br />Conclusions: Sinomenine is a beneficial active agent for the treatment of OA disease.
- Subjects :
- Rats
Animals
Iodoacetic Acid metabolism
Iodoacetic Acid pharmacology
Aggrecans metabolism
Aggrecans pharmacology
Disease Models, Animal
Matrix Metalloproteinases metabolism
Cytokines metabolism
Inflammation Mediators metabolism
Body Weight
Osteoarthritis metabolism
Cartilage, Articular metabolism
Morphinans
Subjects
Details
- Language :
- English
- ISSN :
- 1678-2674
- Volume :
- 39
- Database :
- MEDLINE
- Journal :
- Acta cirurgica brasileira
- Publication Type :
- Academic Journal
- Accession number :
- 38324802
- Full Text :
- https://doi.org/10.1590/acb390924