Back to Search
Start Over
Co-occurrence of bacteria and viruses and serotype distribution of Streptococcus pneumoniae in the nasopharynx of Tanzanian children below 2 years of age following introduction of the PCV13.
- Source :
-
Frontiers in public health [Front Public Health] 2024 Jan 22; Vol. 12, pp. 1298222. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Introduction: Pneumococcal conjugate vaccines have reduced severe disease attributed to vaccine-type pneumococci in children. However, the effect is dependent on serotype distribution in the population and disease development may be influenced by co-occurrence of viral and bacterial pathogens in the nasopharynx.<br />Methods: Following introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in Tanzania we performed repeated cross-sectional surveys, including 775 children below 2 years of age attending primary healthcare centers. All children were sampled from nasopharynx and pneumococci were detected by single-target PCR. Pneumococcal serotypes/groups and presence of viruses and other bacteria were determined by two multiplex PCR assays.<br />Results: The prevalence of PCV13 vaccine-type pneumococci decreased by 50%, but residual vaccine-types were still detected in 21% of the children 2 years after PCV13 introduction. An increase in the non-vaccine-type 15 BC was observed. Pneumococci were often co-occurring with Haemophilus influenzae , and detection of rhino/enterovirus was associated with higher pneumococcal load.<br />Discussion: We conclude that presence of residual vaccine-type and emerging non-vaccine-type pneumococci in Tanzanian children demand continued pneumococcal surveillance. High co-occurrence of viral and bacterial pathogens may contribute to the disease burden and indicate the need of multiple public health interventions to improve child health in Tanzania.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Emgård, Andersson, Gonzales-Siles, Msuya, Nyombi, Nordén, Muro, Lindh, Andersson and Skovbjerg.)
Details
- Language :
- English
- ISSN :
- 2296-2565
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in public health
- Publication Type :
- Academic Journal
- Accession number :
- 38317802
- Full Text :
- https://doi.org/10.3389/fpubh.2024.1298222