Back to Search
Start Over
Structural adaptation of intercalated cells in rat renal cortex to acute metabolic acidosis and alkalosis.
- Source :
-
Journal of ultrastructure research [J Ultrastruct Res] 1985 Jul-Aug; Vol. 92 (1-2), pp. 119-31. - Publication Year :
- 1985
-
Abstract
- The structural responses of cells in the distal convoluted, connecting, and collecting tubule to acute acid/base changes were investigated by electron microscopy. Acute metabolic acidosis was induced by administration of ammonium chloride, and acute metabolic alkalosis by potassium or sodium bicarbonate. Morphometric analyses were performed on micrographs of randomly selected distal nephron cells. No structural responses were found in distal convoluted tubule cells, connecting tubule cells, or principal cells but prominent changes were observed in intercalated cells (I cells). Thus, the surface density of the luminal membrane in I cells was significantly higher in acidotic animals and lower in KHCO3 alkalotic animals than in controls. On the contrary, the surface density of the membrane that bounds apical vesicles was higher in KHCO3 alkalotic and lower in acidotic animals than in controls. These results suggest that the luminal membrane is internalized during alkalosis and that the membrane that bounds apical vesicles is transferred to the luminal membrane during acidosis. Since a proton translocating ATPase may be present in the luminal membrane the observations are consistent with the possibility that cortical I cells participate in the maintenance of acid/base homeostasis.
- Subjects :
- Acidosis urine
Acute Disease
Alkalosis urine
Ammonium Chloride
Animals
Bicarbonates
Female
Hydrogen-Ion Concentration
Microscopy, Electron
Potassium urine
Rats
Rats, Inbred Strains
Sodium urine
Acidosis pathology
Alkalosis pathology
Kidney Cortex ultrastructure
Kidney Tubules ultrastructure
Kidney Tubules, Distal ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0022-5320
- Volume :
- 92
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of ultrastructure research
- Publication Type :
- Academic Journal
- Accession number :
- 3831384
- Full Text :
- https://doi.org/10.1016/0889-1605(85)90133-8