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Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile.
- Source :
-
Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2024 May; Vol. 9 (5), pp. 472-489. Date of Electronic Publication: 2024 Feb 01. - Publication Year :
- 2024
-
Abstract
- Psychedelic compounds, including psilocybin, LSD (lysergic acid diethylamide), DMT (N,N -dimethyltryptamine), and 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), all of which are serotonin 2A receptor agonists, are being investigated as potential treatments. This review aims to summarize the current clinical research on these 4 compounds and mescaline to guide future research. Their mechanism(s) of action, pharmacokinetics, pharmacodynamics, efficacy, and safety were reviewed. While evidence for therapeutic indications, with the exception of psilocybin for depression, is still relatively scarce, we noted no differences in psychedelic effects beyond effect duration. Therefore, it remains unclear whether different receptor profiles contribute to the therapeutic potential of these compounds. More research is needed to differentiate these compounds in order to inform which compounds might be best for different therapeutic uses.<br /> (Copyright © 2024 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Serotonin 5-HT2 Receptor Agonists pharmacology
Serotonin 5-HT2 Receptor Agonists pharmacokinetics
Hallucinogens pharmacokinetics
Hallucinogens pharmacology
Psilocybin pharmacokinetics
Psilocybin pharmacology
Lysergic Acid Diethylamide pharmacology
Lysergic Acid Diethylamide pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 2451-9030
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biological psychiatry. Cognitive neuroscience and neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 38301886
- Full Text :
- https://doi.org/10.1016/j.bpsc.2024.01.007