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Bacterial infection in endometriosis: a silver-lining for the development of new non-hormonal therapy?

Bacterial infection in endometriosis: a silver-lining for the development of new non-hormonal therapy?

Authors :
Khan KN
de Ziegler D
Guo SW
Source :
Human reproduction (Oxford, England) [Hum Reprod] 2024 Apr 03; Vol. 39 (4), pp. 623-631.
Publication Year :
2024

Abstract

The pathogenesis of endometriosis is a hotly debated topic, yet still cloaked in multiple layers of hypothetical theories. A recent report raises the possibility that bacterial infection, especially those of the genus Fusobacterium, may be the cause of endometriosis, at least in certain women. More importantly, the demonstration that treatment with broad-spectrum antibiotics significantly reduced the size of lesions in a mouse endometriosis model rekindles the hope for new non-hormonal treatments. The development of new therapies has been plagued by strings of unsuccessful clinical trials over the last two decades. Is this antibiotic therapy, a silver lining for the research and development of non-hormonal drugs for endometriosis?<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1460-2350
Volume :
39
Issue :
4
Database :
MEDLINE
Journal :
Human reproduction (Oxford, England)
Publication Type :
Academic Journal
Accession number :
38300227
Full Text :
https://doi.org/10.1093/humrep/deae006