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Organo-Pt ii Complexes for Potent Photodynamic Inactivation of Multi-Drug Resistant Bacteria and the Influence of Configuration.
- Source :
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Apr; Vol. 11 (14), pp. e2306936. Date of Electronic Publication: 2024 Jan 31. - Publication Year :
- 2024
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Abstract
- Pt <superscript>II</superscript> based organometallic photosensitizers (PSs) have emerged as novel potent photodynamic inactivation (PDI) reagents through their enhanced intersystem crossing (ISC) processes. Currently, few Pt <superscript>II</superscript> PSs have been investigated as antibacterial materials, with relatively poor performances reported and with structure-activity relationships not well described. Herein, a pair of configurational isomers are reported of Bis-BODIPY (4,4-difluoro-boradizaindacene) embedded Pt <superscript>II</superscript> PSs. The cis-isomer (cis-BBP) displayed enhanced <superscript>1</superscript> O <subscript>2</subscript> generation and better bacterial membrane anchoring capability as compared to the trans-isomer (trans-BBP). The effective PDI concentrations (efficiency > 99.9%) for cis-BBP in Acinetobacter baumannii (multi-drug resistant (MDR)) and Staphylococcus aureus are 400 nM (12 J cm <superscript>-2</superscript> ) and 100 nM (18 J cm <superscript>-2</superscript> ), respectively; corresponding concentrations and light doses for trans-BBP in the two bacteria are 2.50 µM (30 J cm <superscript>-2</superscript> ) and 1.50 µM (18 J cm <superscript>-2</superscript> ), respectively. The 50% and 90% minimum inhibitory concentration (MIC <subscript>50</subscript> and MIC <subscript>90</subscript> ) ratio of trans-BBP to cis-BBP is 22.22 and 24.02 in A. baumannii (MDR); 21.29 and 22.36 in methicillin resistant S. aureus (MRSA), respectively. Furthermore, cis-BBP displays superior in vivo antibacterial performance, with acceptable dark and photoinduced cytotoxicity. These results demonstrate cis-BBP is a robust light-assisted antibacterial reagent at sub-micromolecular concentrations. More importantly, configuration of Pt <superscript>II</superscript> PSs should be an important issue to be considered in further PDI reagents design.<br /> (© 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 2198-3844
- Volume :
- 11
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 38298088
- Full Text :
- https://doi.org/10.1002/advs.202306936