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Effects of umbilical vein flow on midbrain growth and cortical development in late onset fetal growth restricted fetuses: a prospective cross-sectional study.
- Source :
-
Journal of perinatal medicine [J Perinat Med] 2024 Feb 01; Vol. 52 (4), pp. 423-428. Date of Electronic Publication: 2024 Feb 01 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Objectives: To investigate midbrain growth, including corpus callusum (CC) and cerebellar vermis (CV) and cortical development in late fetal growth restricted (FGR) subclassified according to the umbilical vein blood flow (UVBF) values.<br />Methods: This was a prospective study on singleton fetuses late FGR with abnormal placental cerebral ratio (PCR). FGR fetuses were further subdivided into normal (≥fifth centile) and abnormal (<fifth centile) UVBF blood flow corrected for AC (UVBF/AC), neurosonography was performed at 33-34 weeks of gestation to assess CC and CV lengths and the depth of Sylvian fissure (SF), parieto-occipital (POF) and calcarine fissures (CF). Neurosonographic variables were normalized for fetal head circumference size.<br />Results: The study cohort included 60 late FGR, 31 with normal UVBF/AC and 29 with abnormal UVBF/AC values. The latter group showed significant differences in CC (median (interquartile range (IQR) normal 0.96 (0.73-1.16) vs. abnormal UVBF/AC 0.60 (0.47-0.87); p<0.0001)), CV (normal 1.04 (0.75-1.26) vs. abnormal UVBF (AC 0.76 (0.62-1.18)); p=0.0319), SF (normal 0.83 (0.74-0.93) vs. abnormal UVBF/AC 0.56 (0.46-0.68); p<0.0001), POF (normal 0.80 (0.71-0.90) vs. abnormal UVBF/AC l 0.49 (0.39-0.90); p≤0.0072) and CF (normal 0.83 (0.56-1.01) vs. abnormal UVBF/AC 0.72 (0.53-0.80); p<0.029).<br />Conclusions: Late onset FGR fetuses with of reduced umbilical vein flow showed shorter CC and CV length and a delayed cortical development when compared to those with normal umbilical vein hemodynamics. These findings support the existence of a link between abnormal brain development and changes in umbilical vein circulation.<br /> (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
- Subjects :
- Humans
Female
Pregnancy
Prospective Studies
Cross-Sectional Studies
Adult
Fetal Development physiology
Cerebral Cortex diagnostic imaging
Cerebral Cortex blood supply
Cerebral Cortex embryology
Fetal Growth Retardation diagnostic imaging
Fetal Growth Retardation physiopathology
Umbilical Veins diagnostic imaging
Ultrasonography, Prenatal methods
Mesencephalon diagnostic imaging
Mesencephalon blood supply
Mesencephalon embryology
Subjects
Details
- Language :
- English
- ISSN :
- 1619-3997
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of perinatal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38296222
- Full Text :
- https://doi.org/10.1515/jpm-2023-0487