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Role of Anterior Segment Optical Coherence Tomography in Staging and Evaluation of Treatment Response in Infectious Keratitis.
- Source :
-
Cornea [Cornea] 2024 Oct 01; Vol. 43 (10), pp. 1216-1222. Date of Electronic Publication: 2024 Jan 30. - Publication Year :
- 2024
-
Abstract
- Purpose: The aim of this study was to evaluate the role of anterior segment optical coherence tomography during follow-up of infectious keratitis and to assess response to treatment.<br />Methods: This was a prospective, consecutive, observational clinical series of cases. Twenty-three eyes of 23 patients with clinically proven fungal keratitis were included in the study. The patients received medical treatment according to clinical diagnosis, and follow-up was performed weekly. Slit-lamp examination and photography, and anterior segment optical coherence tomography were performed at initial and follow-up visits until corneal healing occurred. The main outcome measures included infiltrate depth, width, and density; central corneal thickness; minimal corneal thickness; corneal thickness at the site of the lesion; and stromal thickness at the center of the lesion.<br />Results: Twenty-three eyes of 23 patients (17 men and 6 women), mean age 42.5 ± 19 (8-66) years, were clinically diagnosed with fungal keratitis. Localization was central in 14 cases and paracentral/peripheral in 9 cases. Healing time was 6 to 12 weeks. Minimal corneal thickness, corneal thickness at the site of lesion, and stromal thickness at the center of lesion, and also infiltrate width and depth changed significantly from the first visit to the healing stage at the last follow-up (0.009, 0.001, 0.007, 0.001, and <0.001, respectively).<br />Conclusions: In cases of fungal keratitis, anterior segment optical coherence tomography can provide the clinician with a quantitative assessment of a number of corneal parameters that can be used to determine effectiveness of therapy and confirm complete healing of the lesions that cannot be achieved by clinical evaluation.<br />Competing Interests: The authors have no funding or conflicts of interest to disclose.<br /> (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Adult
Middle Aged
Prospective Studies
Aged
Adolescent
Young Adult
Child
Antifungal Agents therapeutic use
Follow-Up Studies
Corneal Ulcer microbiology
Corneal Ulcer drug therapy
Corneal Ulcer diagnosis
Corneal Ulcer diagnostic imaging
Visual Acuity physiology
Cornea pathology
Cornea diagnostic imaging
Tomography, Optical Coherence methods
Eye Infections, Fungal drug therapy
Eye Infections, Fungal microbiology
Eye Infections, Fungal diagnosis
Eye Infections, Fungal diagnostic imaging
Anterior Eye Segment diagnostic imaging
Anterior Eye Segment pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4798
- Volume :
- 43
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cornea
- Publication Type :
- Academic Journal
- Accession number :
- 38289764
- Full Text :
- https://doi.org/10.1097/ICO.0000000000003466