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Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Apr; Vol. 20 (4), pp. 2340-2352. Date of Electronic Publication: 2024 Jan 29. - Publication Year :
- 2024
-
Abstract
- Background: We aimed to evaluate the precision of Alzheimer's disease (AD) and neurodegeneration biomarker measurements from venous dried plasma spots (DPS <superscript>v</superscript> <superscript>enous</superscript> ) for the diagnosis and monitoring of neurodegenerative diseases in remote settings.<br />Methods: In a discovery (n = 154) and a validation cohort (n = 115), glial fibrillary acidic protein (GFAP); neurofilament light (NfL); amyloid beta (Aβ) 40, Aβ42; and phosphorylated tau (p-tau181 and p-tau217) were measured in paired DPS <superscript>venous</superscript> and ethylenediaminetetraacetic acid plasma samples with single-molecule array. In the validation cohort, a subset of participants (n = 99) had cerebrospinal fluid (CSF) biomarkers.<br />Results: All DPS <superscript>venous</superscript> and plasma analytes correlated significantly, except for Aβ42. In the validation cohort, DPS <superscript>venous</superscript> GFAP, NfL, p-tau181, and p-tau217 differed between CSF Aβ-positive and -negative individuals and were associated with worsening cognition.<br />Discussion: Our data suggest that measuring blood biomarkers related to AD pathology and neurodegeneration from DPS <superscript>venous</superscript> extends the utility of blood-based biomarkers to remote settings with simplified sampling conditions, storage, and logistics.<br />Highlights: A wide array of biomarkers related to Alzheimer's disease (AD) and neurodegeneration were detectable in dried plasma spots (DPS <superscript>venous</superscript> ). DPS <superscript>venous</superscript> biomarkers correlated with standard procedures and cognitive status. DPS <superscript>venous</superscript> biomarkers had a good diagnostic accuracy discriminating amyloid status. Our findings show the potential interchangeability of DPS <superscript>venous</superscript> and plasma sampling. DPS <superscript>venous</superscript> may facilitate remote and temperature-independent sampling for AD biomarker measurement. Innovative tools for blood biomarker sampling may help recognizing the earliest changes of AD.<br /> (© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 38284555
- Full Text :
- https://doi.org/10.1002/alz.13697