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Development of artificial synapse organizers liganded with a peptide tag for molecularly inducible neuron-microelectrode interface.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Mar 05; Vol. 699, pp. 149563. Date of Electronic Publication: 2024 Jan 22. - Publication Year :
- 2024
-
Abstract
- It has been proposed that cell-type-specific bioelectronic interfaces for neuronal circuits could be established by utilizing the function of synapse organizers. For this purpose, using neurexin-1β and a peptide tag, we engineered compact synapse organizers that do not interact with the naturally occurring receptors but induce presynaptic differentiation upon contact with nanobody-decorated objects in cultured mammalian and chick forebrain neurons. In chick neurons, the engineered organizer exerted synaptogenesis typically in ∼4 h after the contact, even under an air atmosphere at room temperature, thereby providing a useful cellular model for establishing the molecularly inducible neuron-microelectrode interface.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 699
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 38277728
- Full Text :
- https://doi.org/10.1016/j.bbrc.2024.149563