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Impact of pretreatment body mass index on the survival of head and neck cancer patients.
- Source :
-
Head & neck [Head Neck] 2024 Aug; Vol. 46 (8), pp. 1881-1892. Date of Electronic Publication: 2024 Jan 25. - Publication Year :
- 2024
-
Abstract
- Background: Differences in pretreatment body mass index (BMI) have been associated with survival in squamous cell carcinoma of head and neck (SCCHN). We examined effects of BMI on survival in SCCHN patients after stratifying patients by tumor human papillomavirus (HPV) status and subsite.<br />Methods: Totally 2204 SCCHN patients in a prospective study were included in this secondary analysis. Multivariable Cox models were used to evaluate associations between pretreatment BMI and overall survival, disease-specific survival, and disease-free survival.<br />Results: BMI was significantly higher among patients with HPV-positive tumors than HPV-negative tumors. BMI >25 kg/m <superscript>2</superscript> was associated with improved survival, while BMI <18.5 kg/m <superscript>2</superscript> was associated with reduced survival, particularly in patients with HPV-positive oropharyngeal cancer tumors.<br />Conclusions: This exploratory analysis suggests that pretreatment BMI could be an independent prognostic factor of survival outcomes in SCCHN patients, particularly in patients with HPV-positive oropharyngeal cancer tumors. Further prospective investigations are warranted.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Humans
Male
Female
Middle Aged
Prospective Studies
Aged
Prognosis
Papillomavirus Infections complications
Papillomavirus Infections mortality
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell virology
Carcinoma, Squamous Cell therapy
Carcinoma, Squamous Cell pathology
Proportional Hazards Models
Disease-Free Survival
Adult
Oropharyngeal Neoplasms mortality
Oropharyngeal Neoplasms virology
Oropharyngeal Neoplasms therapy
Oropharyngeal Neoplasms pathology
Survival Rate
Survival Analysis
Body Mass Index
Head and Neck Neoplasms mortality
Head and Neck Neoplasms virology
Head and Neck Neoplasms therapy
Head and Neck Neoplasms pathology
Squamous Cell Carcinoma of Head and Neck mortality
Squamous Cell Carcinoma of Head and Neck virology
Squamous Cell Carcinoma of Head and Neck therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 46
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 38269627
- Full Text :
- https://doi.org/10.1002/hed.27659