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The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease.
- Source :
-
Fetal and pediatric pathology [Fetal Pediatr Pathol] 2024 Mar-Apr; Vol. 43 (2), pp. 140-150. Date of Electronic Publication: 2024 Jan 25. - Publication Year :
- 2024
-
Abstract
- Introduction: We examined the relationship between proinflammatory cytokines that occur in the inflammatory reaction in the intestine in Hirschsprung disease (HD) and Hirschsprung-associated enterocolitis (HAEC).<br />Methods: Thirty cases (M:27, F:3) operated on due to HD. The cases were divided into three groups: group 1 with pre and post operative EC, group 2 with post-operative, and group 3 with pre-operative EC. The intestinal segments were evaluated by immunohistochemistry for interleukin 1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6).<br />Results: IL-1β staining was significantly higher in the ganglionic zone of groups with enterocolitis compared to the control group ( p = 0.012). TNF-α staining in the transitional zone of Group 3 and IL-1β staining in the ganglionic zone of Group 1 was significantly higher than the control group ( p = 0.030, p = 0.020).<br />Conclusion: In our study, older age at diagnosis and more than 20% IL-1ß staining in the ganglionic segment were found to be risk factors for HAEC. It is noteworthy that the increase in IL-1ß can be associated with HAEC.
Details
- Language :
- English
- ISSN :
- 1551-3823
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Fetal and pediatric pathology
- Publication Type :
- Academic Journal
- Accession number :
- 38268442
- Full Text :
- https://doi.org/10.1080/15513815.2024.2306280