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Dehydration-Toughing Dual-Solvent Gels with Viscoelastic Transition for Infectious Wound Treatment.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Jun; Vol. 13 (14), pp. e2303655. Date of Electronic Publication: 2024 Mar 03. - Publication Year :
- 2024
-
Abstract
- The modulus of traditional biomedical hydrogels increases exponentially meditated by dehydration-stiffing mechanism, which leads to the failure of interface matching between hydrogels and soft tissue wounds. It is found in the study that the dual-solvent gels exhibit dehydration-toughening mechanism with the slowly increasing modulus that are always match the soft tissue wounds. Therefore, dual-solvent glycerol hydrogels (GCFe <subscript>n-gly</subscript> DGHs) are prepared with hydrophobically modified catechol chitosan (hmCSC) and gelatin based on the supramolecular interactions. GCFe <subscript>n-gly</subscript> DGHs exhibit excellent water retention capacity with a total solvent content exceeding 80%, permanent skin-like modulus within a range of 0.45 to 4.13 kPa, and stable photothermal antibacterial abilities against S, aureus, E. coli, as well as MRSA. Infectious full-thickness rat skin defect model and tissue section analysis indicate that GCFe <subscript>n-gly</subscript> DGHs are able to accelerate infectious wound healing by alleviating the inflammatory response, promoting granulation tissue growth, re-epithelialization, collagen deposition, and vascular regeneration. As a result, GCFe <subscript>n-gly</subscript> DGHs is expected to become the next-generation biological gel materials for infectious wound treatment.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Animals
Rats
Rats, Sprague-Dawley
Staphylococcus aureus drug effects
Wound Infection drug therapy
Escherichia coli drug effects
Gelatin chemistry
Male
Glycerol chemistry
Glycerol pharmacology
Skin drug effects
Viscosity
Hydrogels chemistry
Hydrogels pharmacology
Wound Healing drug effects
Chitosan chemistry
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 38265971
- Full Text :
- https://doi.org/10.1002/adhm.202303655