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Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated heterocycles.
- Source :
-
Beilstein journal of organic chemistry [Beilstein J Org Chem] 2024 Jan 19; Vol. 20, pp. 118-124. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- A visible-light-promoted research protocol for constructing dihydropyrido[1,2- a ]indolone skeletons is herein described proceeding through a cascade cyclization mediated by trifluoromethyl radicals. This method allows the efficient synthesis of various indole derivatives without the need of photocatalysts or transition-metal catalysts. Mechanism experiments indicate that the process involves a radical chain process initiated by the homolysis of Umemoto's reagent. This straightforward method enables a rapid access to heterocycles containing a trifluoromethyl group.<br /> (Copyright © 2024, Yang et al.)
Details
- Language :
- English
- ISSN :
- 1860-5397
- Volume :
- 20
- Database :
- MEDLINE
- Journal :
- Beilstein journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38264451
- Full Text :
- https://doi.org/10.3762/bjoc.20.12