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Effect of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on time to outcome in type 2 diabetes cardiorenal outcome trials.
- Source :
-
Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2024 Feb; Vol. 18 (2), pp. 102945. Date of Electronic Publication: 2024 Jan 12. - Publication Year :
- 2024
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Abstract
- Introduction: In randomized controlled trials (RCTs), treatment effects are commonly reported as hazard ratio, a measure often misinterpreted as a relative risk reduction. The acceleration factor (AF) indicates the extent to which a treatment increases/decreases the time before the occurrence of an outcome and gives useful insights in the interpretation of trials' results.<br />Methods: Using individual time-to-event data reconstructed from Kaplan-Meier plots, we estimated AFs for the primary outcomes (POs) and all-cause mortality in glucagon-like peptide-1 receptor agonists (GLP1-RAs) or sodium-glucose cotransporter-2 inhibitors (SGLT2-is) cardiorenal outcome trials in subjects with type 2 diabetes.<br />Results: AFs were estimated from 28 Kaplan-Meier plots of 19 RCTs. Compared to placebo, most GLP1-RAs increased the time before the onset of POs (from 9 % to 59 %) and all-cause mortality (from 8 to 13 %). Similarly, SGLT2-is increased time before the onset of POs (from 19 % to 87 %) and all-cause mortality (from 13 % to 42 %).<br />Conclusions: The AFs provide a complementary and easier-to-interpret measure of treatment effect that could be useful to improve the shared decision-making.<br />Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alessandro Rizzi reports a relationship with Novo Nordisk Inc that includes: consulting or advisory, speaking and lecture fees, and travel reimbursement. Alessandro Rizzi reports a relationship with Medtronic Inc that includes: speaking and lecture fees. Alessandro Rizzi reports a relationship with Boehringer Ingelheim GmbH that includes: speaking and lecture fees. Alessandro Rizzi reports a relationship with LifeScan Inc that includes: consulting or advisory and speaking and lecture fees. Dario Pitocco, Kamlesh Khunti, Melanie J Davies reports a relationship with Novo Nordisk Inc that includes: consulting or advisory and speaking and lecture fees. Dario Pitocco, Melanie J Davies reports a relationship with Medtronic Inc that includes: consulting or advisory and speaking and lecture fees. Dario Pitocco, Kamlesh Khunti, Melanie J Davies reports a relationship with Boehringer Ingelheim GmbH that includes: consulting or advisory and speaking and lecture fees. Dario Pitocco, Kamlesh Khunti, Melanie J Davies reports a relationship with AstraZeneca Pharmaceuticals LP that includes: consulting or advisory and speaking and lecture fees. Dario Pitocco, Kamlesh Khunti, Melanie J Davies reports a relationship with Eli Lilly and Company that includes: consulting or advisory and speaking and lecture fees. Dario Pitocco, Kamlesh Khunti, Melanie J Davies reports a relationship with Sanofi that includes: consulting or advisory and speaking and lecture fees. Kamlesh Khunti reports a relationship with Merck & Co Inc that includes: consulting or advisory and speaking and lecture fees. Kamlesh Khunti reports a relationship with Bayer Corporation that includes: consulting or advisory and speaking and lecture fees. Kamlesh Khunti reports a relationship with Abbott that includes: consulting or advisory and speaking and lecture fees. Kamlesh Khunti reports a relationship with Roche that includes: consulting or advisory and speaking and lecture fees.<br /> (Copyright © 2024. Published by Elsevier Ltd.)
- Subjects :
- Humans
Glucagon-Like Peptide-1 Receptor agonists
Glucagon-Like Peptide-1 Receptor Agonists
Glucose
Sodium-Glucose Transporter 2
Cardiovascular Diseases
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 epidemiology
Sodium-Glucose Transporter 2 Inhibitors therapeutic use
Sodium-Glucose Transporter 2 Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-0334
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetes & metabolic syndrome
- Publication Type :
- Academic Journal
- Accession number :
- 38262118
- Full Text :
- https://doi.org/10.1016/j.dsx.2024.102945