Back to Search
Start Over
Smart Bactericidal Capsules Based on Cationic Luminescent Nanoclusters for Controllable Treatment of Drug-Resistant Bacterial Infection.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Apr; Vol. 13 (11), pp. e2303686. Date of Electronic Publication: 2024 Feb 05. - Publication Year :
- 2024
-
Abstract
- Effective treatment of drug-resistant bacteria infected wound has been a longstanding challenge for healthcare systems. In particular, the development of novel strategies for controllable delivery and smart release of antimicrobial agents is greatly demanded. Herein, the design of biodegradable microcapsules carrying bactericidal gold nanoclusters (AuNCs) as an attractive platform for the effective treatment of drug-resistant bacteria infective wounds is reported. AuNC capsules are fabricated via the well-controlled layer-by-layer strategy, which possess intrinsic near-infrared fluorescence and good biocompatibility. Importantly, these AuNC capsules exhibit strong, specific antibacterial activity toward both S. aureus and methicillin-resistant S. aureus (MRSA). Further mechanistic studies by fluorescence confocal imaging and inductively coupled plasma mass spectrometry reveal that these AuNC capsules will be degraded in the S. aureus environment rather than E. coli, which then controllably release the loaded cationic AuNCs to exert antibacterial effect. Consequently, these AuNC capsules show remarkable therapeutic effect for the MRSA infected wound on a mouse model, and intrinsic fluorescence property of AuNC capsules enables in situ visualization of wound dressings. This study suggests the great potential of microcapsule-based platform as smart carriers of bactericidal agents for the effective treatment of drug-resistant bacterial infection as well as other therapeutic purposes.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Animals
Mice
Capsules chemistry
Staphylococcal Infections drug therapy
Staphylococcus aureus drug effects
Cations chemistry
Microbial Sensitivity Tests
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Methicillin-Resistant Staphylococcus aureus drug effects
Gold chemistry
Metal Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 38262003
- Full Text :
- https://doi.org/10.1002/adhm.202303686