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Photo- and X-ray Induced Cytotoxicity of CeF 3 -YF 3 -TbF 3 Nanoparticle-Polyvinylpyrrolidone-"Radachlorin" Composites for Combined Photodynamic Therapy.
- Source :
-
Materials (Basel, Switzerland) [Materials (Basel)] 2024 Jan 08; Vol. 17 (2). Date of Electronic Publication: 2024 Jan 08. - Publication Year :
- 2024
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Abstract
- The Ce <subscript>0.5</subscript> Y <subscript>0.35</subscript> Tb <subscript>0.15</subscript> F <subscript>3</subscript> nanoparticles with a CeF <subscript>3</subscript> hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ± 1 nm. The luminescence decay curves of the Ce <subscript>0.5</subscript> Y <subscript>0.35</subscript> Tb <subscript>0.15</subscript> F <subscript>3</subscript> nanoparticles (λ <subscript>em</subscript> = 541 nm, <superscript>5</superscript> D <subscript>4</subscript> - <superscript>7</superscript> F <subscript>5</subscript> transition of Tb <superscript>3+</superscript> ) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb <superscript>3+</superscript> to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was R <subscript>0</subscript> = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%.
Details
- Language :
- English
- ISSN :
- 1996-1944
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Materials (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 38255483
- Full Text :
- https://doi.org/10.3390/ma17020316