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Sexual and Reproductive Health Care after Gonadotoxic Treatment in Females at a Tertiary Pediatric Hospital.
- Source :
-
Journal of pediatric and adolescent gynecology [J Pediatr Adolesc Gynecol] 2024 Jun; Vol. 37 (3), pp. 360-364. Date of Electronic Publication: 2024 Jan 20. - Publication Year :
- 2024
-
Abstract
- Study Objectives: Recommendations from the Children's Oncology Group Long-Term Follow-Up (COG-LTFU) Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer emphasize the importance of reproductive health care, yet little is known regarding adherence to these recommendations and non-fertility-related sexual and reproductive health (SRH) outcomes.<br />Methods: Follow-up of outcomes on the basis of the COG-LTFU guidelines was assessed in female patients who underwent fertility preservation consultation before gonadotoxic therapy between 2016 and 2022 at a single institution and were at least 6 months from treatment completion.<br />Results: We included 140 patients, with a mean time of 2.7 years from treatment completion. Eighty-six patients were 12 years old or older, of whom sexual activity was recorded in 59 (68.7%), and 12 of 31 (38.7%) sexually active patients underwent sexual function assessment. The 57 (66.3%) patients at high risk of premature ovarian insufficiency (POI) at diagnosis were more likely than minimal-risk counterparts (29, 33.7%) to have abnormal uterine bleeding (42.1% vs 17.2%, P = .03), to be diagnosed with POI (29.8% vs 0%, P = .01), and to have sexual activity recorded (77.2% vs 51.7%, P = .03). Of 17 patients with POI, 82.4% were on hormone replacement therapy, and 58.8% had undergone bone mineral density testing.<br />Conclusion: This study adds to the limited literature regarding non-fertility-related SRH outcomes after gonadotoxic therapy and illustrates opportunities to improve adherence to the COG-LTFU guidelines. Increased attention to SRH guidelines may increase detection and treatment of SRH conditions, improving the health and quality of life of female cancer survivors.<br />Competing Interests: Conflicts of Interest The authors report no conflicts of interest or financial disclosures.<br /> (Copyright © 2024. Published by Elsevier Inc.)
- Subjects :
- Humans
Female
Adolescent
Child
Young Adult
Cancer Survivors
Primary Ovarian Insufficiency chemically induced
Hospitals, Pediatric
Adult
Sexual Health
Antineoplastic Agents adverse effects
Neoplasms drug therapy
Neoplasms therapy
Neoplasms complications
Sexual Behavior
Fertility Preservation
Tertiary Care Centers
Reproductive Health
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4332
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of pediatric and adolescent gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 38253233
- Full Text :
- https://doi.org/10.1016/j.jpag.2024.01.004