Cell death.

Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating infected cells. Cell death can be induced by the genetically programmed suicide mechanisms of apoptosis, necroptosis, and pyroptosis, or it can be a consequence of dysregulated metabolism, as in ferroptosis. Here, we review the signaling mechanisms underlying each cell-death pathway, discuss how impaired or excessive activation of the distinct cell-death processes can promote disease, and highlight existing and potential therapies for redressing imbalances in cell death in cancer and other diseases.
Competing Interests: Declaration of interests K.N., N.K., and V.M.D. are employees of Genentech. A.S. is an employee of WEHI: Walter and Eliza Hall Institute of Medical Research, which received royalties and milestone payments from Venetoclax. A.S. has also received funding for some of his research from Servier Laboratories.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)